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Brain Res. 1991 Jun 14;551(1-2):308-10.

A conditioned stimulus decreases extracellular dopamine in the nucleus accumbens after the development of a learned taste aversion.

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Department of Psychology, Princeton University, NJ 08544-1010.


The conditioned taste aversion (CTA) paradigm and microdialysis were used to determine if extracellular dopamine in the nucleus accumbens is related to the reward value of a stimulus. Intraorally applied saccharin caused a 37% increase in DA in naive rats and a 40% decrease in subjects with a CTA to this taste. These results suggest that accumbens DA is not just a function of arousal but is related to stimulus reward.

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