Format

Send to

Choose Destination
Int J Radiat Oncol Biol Phys. 2009 Jul 15;74(4):1199-202. doi: 10.1016/j.ijrobp.2008.09.049. Epub 2009 Jan 7.

Low-dose involved-field radiotherapy as alternative treatment of nodular lymphocyte predominance Hodgkin's lymphoma.

Author information

1
Department of Radiotherapy, The Netherlands Cancer Institute Amsterdam, Amsterdam, The Netherlands. r.haas@nki.nl

Abstract

PURPOSE:

Nodular lymphocyte predominance Hodgkin's lymphoma is a very rare disease, characterized by an indolent clinical course, with sometimes very late relapses occurring in a minority of all patients. Considerable discussion is ongoing on the treatment of primary and relapsed disease.

PATIENTS AND METHODS:

A group of 9 patients were irradiated to a dose of 4 Gy on involved areas only.

RESULTS:

After a median follow-up of 37 months (range, 6-66), the overall response rate was 89%. Six patients had complete remission (67%), two had partial remission (22%), and one had stable disease (11%). Of 8 patients, 5 developed local relapse 9-57 months after radiotherapy. No toxicity was noted.

CONCLUSION:

In nodular lymphocyte predominance Hodgkin's lymphoma, low-dose radiotherapy provided excellent response rates and lasting remissions without significant toxicity.

PMID:
19131186
DOI:
10.1016/j.ijrobp.2008.09.049
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center