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Fertil Steril. 2010 Mar 1;93(4):1244-7. doi: 10.1016/j.fertnstert.2008.11.017. Epub 2009 Jan 7.

Association study of vascular endothelial growth factor polymorphisms with the risk of recurrent spontaneous abortion.

Author information

1
Department of Obstetrics and Gynecology, College of Medicine, Pochon CHA University, Seongnam, South Korea.

Abstract

OBJECTIVE:

To investigate the association of vascular endothelial growth factor (VEGF) polymorphisms (-2578C>A, -1154G>A, -634G>C, 936C>T) with idiopathic recurrent spontaneous abortion (RSA) in Koreans.

DESIGN:

Prospective case-control study.

SETTING:

University-based hospital.

PATIENT(S):

Two hundred and fifteen patients with a history of two or more unexplained consecutive pregnancy losses and 113 healthy controls with at least one live birth and no history of pregnancy loss.

INTERVENTION(S):

None.

MAIN OUTCOME MEASURE(S):

Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analyses were performed for the -2578C>A and 936C>T genotypes. Real-time PCR was also used to analyze the -1154G>A and -634G>C genotypes.

RESULT(S):

The GA (adjusted odds ratio [AOR] 2.774; 95% confidence interval [CI] 1.512-5.092) genotype of the VEGF -1154G>A polymorphism was significantly different between women with idiopathic RSA and controls. The difference in overall (GA + AA) frequency was also marginally significant between the controls and patients with idiopathic RSA (AOR, 2.006; 95% CI, 1.158-3.473). The differences in frequencies of the A-A-G-T and C-A-G-T haplotypes of the VEGF polymorphisms (-2578C>A, -1154G>A, -634G>C, 936C>T) were marginally significant between the patient and control groups.

CONCLUSION(S):

This study suggests that VEGF polymorphisms and haplotypes are a genetic determinant for the risk of idiopathic RSA in Korean women.

[Indexed for MEDLINE]

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