On the biosynthesis and biological role of eoxins and 15-lipoxygenase-1 in airway inflammation and Hodgkin lymphoma

Prostaglandins Other Lipid Mediat. 2009 Sep;89(3-4):120-5. doi: 10.1016/j.prostaglandins.2008.12.003. Epub 2008 Dec 14.

Abstract

This mini-review is focused on the enzyme 15-lipoxygenase-1 (15-LO-1) and eoxins in airway inflammatory diseases and Hodgkin lymphoma. Several studies have demonstrated increased expression and activity of 15-LO-1 in the respiratory tissue from asthma patients , indicating a pathophysiological role of this enzyme in airway inflammation. Eoxins were recently identified as pro-inflammatory metabolites of arachidonic acid, formed through the 15-LO-1 pathway, in human eosinophils, mast cells, airway epithelial cells and Hodgkin lymphoma. Mice deficient of 12/15-LO, the ortholog to human 15-LO-1, had an attenuated allergic airway inflammation compared to wild type controls, also indicating a pathophysiological role of this enzyme in respiratory inflammation. The putative therapeutic implications of 15-LO-1 inhibitors in the treatment of asthma, chronic obstructive pulmonary disorder and Hodgkin lymphoma are discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Arachidonate 12-Lipoxygenase / deficiency
  • Arachidonate 12-Lipoxygenase / genetics
  • Arachidonate 12-Lipoxygenase / metabolism
  • Arachidonate 15-Lipoxygenase / deficiency
  • Arachidonate 15-Lipoxygenase / genetics
  • Arachidonate 15-Lipoxygenase / metabolism*
  • Asthma / enzymology
  • Asthma / metabolism*
  • Eosinophils / metabolism
  • Hodgkin Disease / enzymology
  • Hodgkin Disease / metabolism*
  • Humans
  • Inflammation / enzymology
  • Leukotriene D4 / analogs & derivatives*
  • Leukotriene D4 / metabolism
  • Leukotrienes / metabolism*
  • Lung / enzymology
  • Mice
  • Organ Specificity
  • Pulmonary Disease, Chronic Obstructive / enzymology
  • Pulmonary Disease, Chronic Obstructive / metabolism*
  • Reed-Sternberg Cells / enzymology
  • Reed-Sternberg Cells / pathology

Substances

  • 12-15-lipoxygenase
  • Leukotrienes
  • Leukotriene D4
  • Arachidonate 12-Lipoxygenase
  • Arachidonate 15-Lipoxygenase