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Pathol Oncol Res. 2009 Sep;15(3):487-93. doi: 10.1007/s12253-008-9143-8.

Beclin-1 expression is a predictor of clinical outcome in patients with esophageal squamous cell carcinoma and correlated to hypoxia-inducible factor (HIF)-1alpha expression.

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  • 1Division of Thoracic Oncology, West China Hospital, Cancer Center, West China School of Clinical Medicine, Sichuan University, 37, Guoxue Lane, Chengdu 610041, China. yongshun2007@gmail.com

Abstract

In the present study, we examined the relationship between Beclin-1 expression and HIF-1alpha expression in esophageal squamous cell carcinoma(ESCC). There was a loss of Beclin-1 protein expression in 33% of ESCCs. Beclin-1 expression significantly correlated with depth of invasion, lymph node metastasis and clinical stage. Among the 54 patients, The survival rate of the Beclin-1-positive group was better than that of the Beclin-1-negative group. Twenty-five of the 54 (46%) tumor specimens showed high levels of HIF-1alpha immunoreactivity. Beclin-1 expression was associated with HIF-1alpha expression. The survival rate of patients with Beclin-1-positive and HIF-1alpha-low tumors was significantly higher than that of the other groups. These results suggest that Beclin-1 and HIF-1alpha expression are important determinants of survival in ESCCs.

PMID:
19130303
PMCID:
PMC2791489
DOI:
10.1007/s12253-008-9143-8
[PubMed - indexed for MEDLINE]
Free PMC Article
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