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J Nat Prod. 2009 Jan;72(1):177-81. doi: 10.1021/np800559z.

Cytotoxic spirostane-type saponins from the roots of Chlorophytum borivilianum.

Author information

1
Laboratoire de Pharmacognosie, Unite de Molecules d'Interet Biologique, UMIB UPRES-EA 3660, Faculte de Pharmacie, Universite de Bourgogne, 21079 Dijon Cedex, France.

Abstract

Four new spirostane-type saponins named borivilianosides E-H (1-4) were isolated from an ethanol extract of the roots of Chlorophytum borivilianum together with two known steroid saponins (5 and 6). The structures of 1-4 were elucidated using mainly 2D NMR spectroscopic techniques and mass spectrometry. The cytotoxicity of borivilianosides F (2), G (3), and H (4) and three known compounds was evaluated using two human colon cancer cell lines (HT-29 and HCT 116).

PMID:
19128156
DOI:
10.1021/np800559z
[Indexed for MEDLINE]

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