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J Clin Pathol. 2009 Mar;62(3):195-200. doi: 10.1136/jcp.2008.058735. Epub 2009 Jan 6.

RNA interference screening demystified.

Author information

1
The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK. Chris.Lord@icr.ac.uk

Abstract

Genetic screens, where the effects of modifying gene function on cell behaviour are assessed in a systematic fashion, have for some time provided useful information to those interested in disease pathogenesis and treatment. Genetic screens exploiting the phenomenon of RNA interference (RNAi) are now becoming commonplace. This article explains the different RNAi screen formats and describes some of the applications of RNAi screening that may be pertinent to the research pathologist.

PMID:
19126568
PMCID:
PMC2652024
DOI:
10.1136/jcp.2008.058735
[Indexed for MEDLINE]
Free PMC Article

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