Format

Send to

Choose Destination
See comment in PubMed Commons below
Biochem J. 2009 Apr 1;419(1):57-63. doi: 10.1042/BJ20081866.

The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4.

Author information

1
Department of Medicine, Clinical Sciences Division, Room 7344, Medical Science Building, University of Toronto, Toronto, 1 Kings College Circle, Ontario, Canada.

Abstract

The inositol phosphatase, MTMR4 (myotubularin-related protein 4), was identified as a novel interactor of the ubiquitin ligase Nedd4 (neural-precursor-cell-expressed developmentally down-regulated 4). hMTMR4 (human MTMR4) and Nedd4 co-immunoprecipitated and co-localized to late endosomes. The PY (Pro-Tyr) motif of hMTMR4 binds to WW (Trp-Trp) domains of hNedd4. MTMR4 expression was decreased in atrophying muscle, whereas Nedd4 expression was increased and hMTMR4 was ubiquitinated by hNedd4, suggesting that this novel interaction may underlie the biological process of muscle breakdown.

PMID:
19125695
PMCID:
PMC2657291
DOI:
10.1042/BJ20081866
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Support Center