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J Infect Dis. 2009 Feb 15;199(4):532-6. doi: 10.1086/596511.

Reduced susceptibility to vancomycin influences pathogenicity in Staphylococcus aureus infection.

Author information

1
Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02215, USA. apeleg@bidmc.harvard.edu

Abstract

In the present study, we demonstrated the utility of the nonmammalian model system Galleria mellonella for studying the pathogenesis of Staphylococcus aureus infection. By use of clinical and laboratory strains that had been exposed to vancomycin, we showed that both agr functional status and vancomycin minimum inhibitory concentration are determinants associated with the virulence of S. aureus in G. mellonella. These results show that G. mellonella can be effectively used to facilitate the in vivo study of S. aureus virulence and, more specifically, the relationship between antibiotic drug resistance and the pathogenesis of infection.

PMID:
19125671
PMCID:
PMC3750955
DOI:
10.1086/596511
[Indexed for MEDLINE]
Free PMC Article

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