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Org Lett. 2009 Feb 5;11(3):633-6. doi: 10.1021/ol802709x.

Mycangimycin, a polyene peroxide from a mutualist Streptomyces sp.

Author information

1
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.

Abstract

A mutualist actinomycete of the southern pine beetle, Dendroctonus frontalis, produces a polyene peroxide with pronounced antifungal activity. Its structure, absolute configuration, and biological activity were determined by spectral analysis, chemical modification followed by the modified Mosher method, and growth inhibitory assays, respectively.

PMID:
19125624
PMCID:
PMC2640424
DOI:
10.1021/ol802709x
[Indexed for MEDLINE]
Free PMC Article

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