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Pediatr Radiol. 2009 Jun;39(6):591-7. doi: 10.1007/s00247-008-1090-8. Epub 2009 Jan 6.

Automatic determination of Greulich and Pyle bone age in healthy Dutch children.

Author information

1
Department of Radiology, Academic Medical Center Amsterdam, Amsterdam Zuid-Oost, The Netherlands. r.r.vanrijn@amc.uva.nl

Abstract

BACKGROUND:

Bone age (BA) assessment is a routine procedure in paediatric radiology, for which the Greulich and Pyle (GP) atlas is mostly used. There is rater variability, but the advent of automatic BA determination eliminates this.

OBJECTIVE:

To validate the BoneXpert method for automatic determination of skeletal maturity of healthy children against manual GP BA ratings.

MATERIALS AND METHODS:

Two observers determined GP BA with knowledge of the chronological age (CA). A total of 226 boys with a BA of 3-17 years and 179 girls with a BA of 3-15 years were included in the study. BoneXpert's estimate of GP BA was calibrated to agree on average with the manual ratings based on several studies, including the present study.

RESULTS:

Seven subjects showed a deviation between manual and automatic BA in excess of 1.9 years. They were re-rated blindly by two raters. After correcting these seven ratings, the root mean square error between manual and automatic rating in the 405 subjects was 0.71 years (range 0.66-0.76 years, 95% CI). BoneXpert's GP BA is on average 0.28 and 0.20 years behind the CA for boys and girls, respectively.

CONCLUSION:

BoneXpert is a robust method for automatic determination of BA.

PMID:
19125243
DOI:
10.1007/s00247-008-1090-8
[Indexed for MEDLINE]

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