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Nat Neurosci. 2009 Feb;12(2):119-21. doi: 10.1038/nn.2240. Epub 2009 Jan 4.

Collagen VI protects neurons against Abeta toxicity.

Author information

1
Gladstone Institute of Neurological Disease, 1650 Owens Street, San Francisco, California 94158, USA.

Abstract

Amyloid-beta (Abeta) peptides, widely presumed to cause Alzheimer's disease, increased mouse neuronal expression of collagen VI through a mechanism involving transforming growth factor signaling. Reduction of collagen VI augmented Abeta neurotoxicity, whereas treatment of neurons with soluble collagen VI blocked the association of Abeta oligomers with neurons, enhanced Abeta aggregation and prevented neurotoxicity. These results identify collagen VI as an important component of the neuronal injury response and demonstrate its neuroprotective potential.

PMID:
19122666
PMCID:
PMC2812922
DOI:
10.1038/nn.2240
[Indexed for MEDLINE]
Free PMC Article

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