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Bioorg Med Chem Lett. 2009 Feb 1;19(3):654-7. doi: 10.1016/j.bmcl.2008.12.049. Epub 2008 Dec 24.

The synthesis and structure-activity relationship of substituted N-phenyl anthranilic acid analogs as amyloid aggregation inhibitors.

Author information

1
Pfizer Global Research and Development, Ann Arbor Laboratories, 2800 Plymouth Rd., Ann Arbor, MI 48105, USA.

Abstract

It is believed that beta-amyloid aggregation is an important event in the development of Alzheimer's disease. In the course of our studies to identify beta-amyloid aggregation inhibitors, a series of N-phenyl anthranilic acid analogs were synthesized and studied for beta-amyloid inhibition activity. The synthesis, structure-activity relationship, and in vivo activity of these analogs are discussed.

PMID:
19121939
DOI:
10.1016/j.bmcl.2008.12.049
[Indexed for MEDLINE]

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