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Bioorg Med Chem Lett. 2009 Feb 1;19(3):650-3. doi: 10.1016/j.bmcl.2008.12.056. Epub 2008 Dec 24.

Carbonic anhydrase inhibitors: inhibition studies of a coral secretory isoform with inorganic anions.

Author information

1
Centre Scientifique de Monaco, Avenue Saint-Martin, MC-98000 Principality of Monaco, Monaco.

Abstract

The inhibition of a coral carbonic anhydrase (CA, EC 4.2.1.1) has been investigated with a series of inorganic anions such as halogenides, pseudohalogenides, bicarbonate, carbonate, nitrate, nitrite, hydrogen sulfide, bisulfite, perchlorate, sulfate. The full-length scleractinian coral Stylophora pistillata CA, STPCA, has a significant catalytic activity for the physiological reaction of CO(2) hydration to bicarbonate, similarly to the ubiquitous human isoforms hCA I (cytosolic) and hCA VI (secreted). The best STPCA anion inhibitors were bromide, iodide, carbonate, and sulfamate, with inhibition constants of 9.0-10.0 microM.

PMID:
19121582
DOI:
10.1016/j.bmcl.2008.12.056
[Indexed for MEDLINE]

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