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FEBS Lett. 2009 Jan 22;583(2):470-4. doi: 10.1016/j.febslet.2008.12.053. Epub 2008 Dec 31.

Acetyl-l-carnitine inhibits TNF-alpha-induced insulin resistance via AMPK pathway in rat skeletal muscle cells.

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1
Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, PR China.

Abstract

In this study, we demonstrated effects of acetyl-l-carnitine (ALC) on insulin resistance induced by tumor necrosis factor-alpha (TNF-alpha) in rat L6 cells. TNF-alpha downregulated insulin-stimulated glucose uptake and increased Serine 307 phosphorylation of insulin receptor substrate-1 (IRS-1). However, the treatment of ALC improved insulin-stimulated glucose uptake via AMP-activated protein kinase (AMPK) activation in a dose-dependent manner. Together, our data suggest that ALC inhibits TNF-alpha-induced insulin resistance through AMPK pathway in skeletal muscle cells.

PMID:
19121314
DOI:
10.1016/j.febslet.2008.12.053
[Indexed for MEDLINE]
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