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Biol Psychiatry. 1991 Aug 15;30(4):383-400.

Limbic/mesolimbic connections and the pathogenesis of schizophrenia.

Author information

1
Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri 63110.

Abstract

The development of models of the pathogenesis of neuropsychiatric diseases that build on recent advances in chemical neuroanatomy will help to guide future research. The interconnections among limbic, basal ganglia, and cortical structures are used to form the basis of a hypothesis of the pathogenesis of schizophrenia. The adaptive capacity of subcortical dopamine systems is advanced as an explanation of the many states of the disease.

PMID:
1912130
DOI:
10.1016/0006-3223(91)90295-w
[Indexed for MEDLINE]

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