Send to

Choose Destination
Nat Rev Genet. 2009 Feb;10(2):83-93. doi: 10.1038/nrg2506.

Fundamental concepts in genetics: genetics and the understanding of selection.

Author information

Department of Biology and Biochemistry, University of Bath, Somerset, BA2 7AY, UK.


At first sight selection is a simple notion, and some consider it the most important evolutionary force. But how important is selection, is it really so trivial to understand and what are the alternatives? Here I discuss how genetics is crucial for addressing all of these questions: genetics allowed the concept of natural selection to become viable, it contributed to our understanding of the complexities of selection and it spurred the development of competing models of evolution. Understanding how and why selection acts has important potential applications, from understanding the mechanisms of disease and microbial resistance, to improving the design of transgenes and drugs.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center