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J Am Acad Dermatol. 2008 Nov;59(5 Suppl):S99-101. doi: 10.1016/j.jaad.2008.05.007.

Acquired cutis laxa associated with heavy chain deposition disease.

Author information

1
Department of Dermatology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390-9190, USA.

Abstract

Acquired cutis laxa (generalized acquired elastolysis) is a condition of unknown etiology characterized by a degeneration of elastic fibers in the skin, resulting in laxity with reduced elastic recoil. We describe a patient with acquired cutis laxa associated with an underlying heavy chain deposition disease. Direct immunofluorescence testing of lesional skin demonstrated immunoglobulin G deposition on elastic fibers, suggesting that in some cases, cutis laxa may have an immune-mediated etiopathogenesis.

PMID:
19119136
DOI:
10.1016/j.jaad.2008.05.007
[Indexed for MEDLINE]

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