Format

Send to

Choose Destination
See comment in PubMed Commons below
Cell Mol Immunol. 2008 Dec;5(6):401-6. doi: 10.1038/cmi.2008.50.

Generation and regulation of CD8(+) regulatory T cells.

Author information

1
Department of Cancer Immunology & AIDS, Dana-Farber Cancer Institute and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA. lu.linrong@gmail.com

Abstract

Research into the suppressive activity of CD4(+)FoxP3(+) T regulatory cells (Treg) has defined a sublineage of CD4(+) cells that contribute to self-tolerance and resistance to autoimmune disease. Much less attention has been given to the potential contribution of regulatory sublineages of CD8(+) cells. Analysis of a small fraction of CD8(+) cells that target autoreactive CD4(+) cells through recognition of the MHC class Ib molecule Qa-1 in mouse and HLA-E in human has revitalized interest in CD8(+) Treg. Here we summarize recent progress and future directions of research into the role of this CD8(+) sublineage in resistance to autoimmune disease.

PMID:
19118505
PMCID:
PMC4072402
DOI:
10.1038/cmi.2008.50
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group Icon for PubMed Central
    Loading ...
    Support Center