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Br J Psychiatry. 2009 Jan;194(1):1-3. doi: 10.1192/bjp.bp.108.054767.

Antidepressants on trial: how valid is the evidence?

Abstract

A recent meta-analysis concluded that newer antidepressant drugs are equivalent to or no better than placebos, a conclusion at some variance with their commonly judged clinical effectiveness. The 'disconnect' between randomised controlled trials and clinical practice would benefit from dissection of contributing factors, and redressing limitations to current trial procedures.

PMID:
19118316
DOI:
10.1192/bjp.bp.108.054767
[Indexed for MEDLINE]

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