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J Biol Chem. 2009 May 1;284(18):11755-9. doi: 10.1074/jbc.R800071200. Epub 2008 Dec 30.

PTEN, stem cells, and cancer stem cells.

Author information

1
Department of Molecular and Medical Pharmacology, University of California, Los Angeles, California 90095, USA. rhill@mednet.ucla.edu

Abstract

Like normal stem cells, "cancer stem cells" have the capacity for indefinite proliferation and generation of new cancerous tissues through self-renewal and differentiation. Among the major intracellular signaling pathways, WNT, SHH, and NOTCH are known to be important in regulating normal stem cell activities, and their alterations are associated with tumorigenesis. It has become clear recently that PTEN (phosphatase and tensin homologue) is also critical for stem cell maintenance and that PTEN loss can cause the development of cancer stem cells and ultimately tumorigenesis.

PMID:
19117948
PMCID:
PMC2673242
DOI:
10.1074/jbc.R800071200
[Indexed for MEDLINE]
Free PMC Article
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