Format

Send to

Choose Destination
Bioorg Med Chem Lett. 2009 Feb 1;19(3):710-3. doi: 10.1016/j.bmcl.2008.12.043. Epub 2008 Dec 14.

Japonicones A-D, bioactive dimeric sesquiterpenes from Inula japonica Thunb.

Author information

1
School of Pharmacy, Shanghai Jiao Tong University, MinHang DongChuan Rd800, Shanghai 200240, PR China.

Erratum in

  • Bioorg Med Chem Lett. 2010 Sep 15;20(18):5584.

Abstract

Four new dimeric sesquiterpene lactones japonicones A-D (1-4), comprised by eudesmane and guaiane sesquiterpenes, were isolated from the aerial part of Inula japonica Thunb. The structures and stereochemistry of 1-4 were elucidated by use of 2D NMR spectroscopic techniques, X-ray crystallography and modified Mosher method. Japonicone A (1) showed the most potent cytotoxicities against four tumor cell lines, A549, LOVO, CEM and MDA-MB-435.

PMID:
19117757
DOI:
10.1016/j.bmcl.2008.12.043
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center