Format

Send to

Choose Destination
See comment in PubMed Commons below
Anal Chem. 2009 Jan 1;81(1):503-8. doi: 10.1021/ac801912t.

Highly specific enrichment of glycopeptides using boronic acid-functionalized mesoporous silica.

Author information

1
Department of Chemistry and Institutes of Biomedical Sciences and Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai 200433, P.R. China.

Abstract

A novel boronic acid functionalized mesoporous silica, which holds the attractive features of high surface area and large accessible porosity, was developed to enrich glycopeptides. This is the first time that mesoporous material has been introduced into glycoproteome. In comparison to direct (traditional) analysis, this novel method enabled 2 orders of magnitude improvement in the detection limit of glycopeptides. The unbiased nature of organo-boronic acid groups also made this method applicable to all kinds of glycopeptides regardless of their sizes, structures, and hydrophilicities.

PMID:
19117470
DOI:
10.1021/ac801912t
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for American Chemical Society
    Loading ...
    Support Center