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Nat Rev Microbiol. 2009 Feb;7(2):129-43. doi: 10.1038/nrmicro1949. Epub 2008 Dec 31.

Reconstruction of biochemical networks in microorganisms.

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1
Department of Bioengineering, University of California, San Diego, La Jolla, California 92093, USA.

Abstract

Systems analysis of metabolic and growth functions in microbial organisms is rapidly developing and maturing. Such studies are enabled by reconstruction, at the genomic scale, of the biochemical reaction networks that underlie cellular processes. The network reconstruction process is organism specific and is based on an annotated genome sequence, high-throughput network-wide data sets and bibliomic data on the detailed properties of individual network components. Here we describe the process that is currently used to achieve comprehensive network reconstructions and discuss how these reconstructions are curated and validated. This review should aid the growing number of researchers who are carrying out reconstructions for particular target organisms.

PMID:
19116616
PMCID:
PMC3119670
DOI:
10.1038/nrmicro1949
[Indexed for MEDLINE]
Free PMC Article
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