Format

Send to

Choose Destination
Nat Methods. 2009 Jan;6(1):39-46. doi: 10.1038/nmeth.1284.

Literature-curated protein interaction datasets.

Author information

1
Center for Cancer Systems Biology and Department of Cancer Biology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, USA. michael_cusick@dfci.harvard.edu

Abstract

High-quality datasets are needed to understand how global and local properties of protein-protein interaction, or 'interactome', networks relate to biological mechanisms, and to guide research on individual proteins. In an evaluation of existing curation of protein interaction experiments reported in the literature, we found that curation can be error-prone and possibly of lower quality than commonly assumed.

Comment in

PMID:
19116613
PMCID:
PMC2683745
DOI:
10.1038/nmeth.1284
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center