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Proc Natl Acad Sci U S A. 2009 Jan 6;106(1):55-60. doi: 10.1073/pnas.0811914106. Epub 2008 Dec 30.

Wnt signaling targets ETO coactivation domain of TAF4/TFIID in vivo.

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1
Howard Hughes Medical Institute, Li Ka-Shing Center for Biomedical and Sciences, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.

Abstract

Understanding the diverse activities of the multisubunit core promoter recognition complex TFIID in vivo requires knowledge of how individual subunits contribute to overall functions of this TATA box-binding protein (TBP)/TBP-associated factor (TAF) complex. By generating altered holo-TFIID complexes in Drosophila we identify the ETO domain of TAF4 as a coactivator domain likely targeted by Pygopus, a protein that is required for Wingless-induced transcription of naked cuticle. These results establish a coactivator function of TAF4 and provide a strategy to dissect mechanisms of TFIID function in vivo.

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PMID:
19116271
PMCID:
PMC2629200
DOI:
10.1073/pnas.0811914106
[Indexed for MEDLINE]
Free PMC Article
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