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J Virol. 2009 Mar;83(6):2765-9. doi: 10.1128/JVI.02088-08. Epub 2008 Dec 30.

Cell type-specific induction and inhibition of apoptosis by Herpes Simplex virus type 2 ICP10.

Author information

1
Department of Pediatrics, Center for Infectious Diseases and Microbiology Translational Research, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA.

Abstract

Herpes simplex virus (HSV) inhibits apoptosis induced by external stimuli in epithelial cells. In contrast, apoptosis is the primary outcome in HSV-infected lymphocytes. Here, we show that HSV type 2 (HSV-2) gene expression appears to be necessary for the induction of apoptosis in Jurkat cells, a T-cell leukemia line. HSV-2 ICP10 gene expression is sufficient to induce apoptosis in Jurkat cells, while its expression protects epithelial HEp-2 cells from apoptosis triggered by cycloheximide and tumor necrosis factor alpha. Thus, the effect of HSV-2 gene expression on the cellular apoptotic pathway appears to depend on the specific cell type.

PMID:
19116254
PMCID:
PMC2648263
DOI:
10.1128/JVI.02088-08
[Indexed for MEDLINE]
Free PMC Article
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