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Emerg Infect Dis. 2009 Jan;15(1):19-23. doi: 10.3201/eid1501.080073.

Human infection with highly pathogenic avian influenza virus (H5N1) in northern Vietnam, 2004-2005.

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1
National Institute of Infectious and Tropical Diseases, Hanoi, Vietnam.

Abstract

We performed a retrospective case-series study of patients with influenza A (H5N1) admitted to the National Institute of Infectious and Tropical Diseases in Hanoi, Vietnam, from January 2004 through July 2005 with symptoms of acute respiratory tract infection, a history of high-risk exposure or chest radiographic findings such as pneumonia, and positive findings for A/H5 viral RNA by reverse transcription-PCR. We investigated data from 29 patients (mean age 35.1 years) of whom 7 (24.1%) had died. Mortality rates were 20% (5/25) and 50% (2/4) among patients treated with or without oseltamivir (p = 0.24), respectively, and were 33.3% (5/15) and 14.2% (2/14) among patients treated with and without methylprednisolone (p = 0.39), respectively. After exact logistic regression analysis was adjusted for variation in severity, no significant effectiveness for survival was observed among patients treated with oseltamivir or methylprednisolone.

PMID:
19116044
PMCID:
PMC2660684
DOI:
10.3201/eid1501.080073
[Indexed for MEDLINE]
Free PMC Article
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