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Mol Membr Biol. 2009 Jan;26(1):67-79. doi: 10.1080/09687680802620351. Epub 2008 Dec 29.

The fat controller: roles of palmitoylation in intracellular protein trafficking and targeting to membrane microdomains (Review).

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1
The Centre for Integrative Physiology, School of Biomedical Sciences, University of Edinburgh, Edinburgh, UK.

Abstract

The attachment of palmitic acid to the amino acid cysteine via thioester linkage (S-palmitoylation) is a common post-translational modification of eukaryotic proteins. In this review, we discuss the role of palmitoylation as a versatile protein sorting signal, regulating protein trafficking between distinct intracellular compartments and the micro-localization of proteins within membranes.

PMID:
19115144
DOI:
10.1080/09687680802620351
[Indexed for MEDLINE]
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