Format

Send to

Choose Destination
Cell Res. 2009 Jan;19(1):36-46. doi: 10.1038/cr.2008.325.

Nucleocytoplasmic shuttling of Smad proteins.

Author information

1
Laboratory of Developmental Signalling, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3PX, UK. caroline.hill@cancer.org.uk

Abstract

Nuclear accumulation of active Smad complexes is crucial for transduction of transforming growth factor beta (TGF-beta)-superfamily signals from transmembrane receptors into the nucleus. It is now clear that the nucleocytoplasmic distributions of Smads, in both the absence and the presence of a TGF-beta-superfamily signal, are not static, but instead the Smads are continuously shuttling between the nucleus and the cytoplasm in both conditions. This article presents the evidence for continuous nucleocytoplasmic shuttling of Smads. It then reviews different mechanisms that have been proposed to mediate Smad nuclear import and export, and discusses how the Smad steady-state distributions in the absence and the presence of a TGF-beta-superfamily signal are established. Finally, the biological relevance of continuous nucleocytoplasmic shuttling for signaling by TGF-beta superfamily members is discussed.

PMID:
19114992
DOI:
10.1038/cr.2008.325
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center