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Blood Transfus. 2008 Oct;6(4):220-4.

Peripheral blood CD5-positive B lymphocytes (B-1a cells) after allogeneic stem cell transplantation for acute myeloid leukaemia in humans.

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  • 1Dipartimento di Medicina Clinica e Sperimentale, Sezione di Ematologia, Universit√† di Verona, Italy. dino.veneri@univr.it

Abstract

BACKGROUND:

Only few data are available in literature regarding the reconstitution of B- 1a cells after allogeneic bone marrow transplantation performed for haematological malignancies.

METHODS:

In this study we used flow cytometry to assess the reconstitution of the peripheral blood B-1a cell compartment after allogeneic peripheral blood stem cell transplantation. Cytometric analyses were performed over time on 11 consecutive patients undergoing allogeneic peripheral blood stem cell transplantation for acute myeloid leukaemia in our Haematology Unit and the results were compared with available data regarding B- 1a cell reconstitution after allogeneic bone marrow stem cell transplantation.

RESULTS:

In spite of an earlier recovery of B-1a cells in the peripheral blood after allogeneic bone marrow transplantation, the reconstitution of this B-cell subset was similar, regardless of the source of stem cells employed.

CONCLUSIONS:

Further studies are necessary in order to clarify the origin of B-1a cells in humans in health and illness.

PMID:
19112737
PMCID:
PMC2626909
[PubMed - indexed for MEDLINE]
Free PMC Article
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