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PLoS One. 2008;3(12):e4060. doi: 10.1371/journal.pone.0004060. Epub 2008 Dec 29.

Asthma is inversely associated with Helicobacter pylori status in an urban population.

Author information

1
Department of Medicine, New York University School of Medicine, New York City, New York, USA. reibmj01@gcrc.med.nyu.edu

Abstract

BACKGROUND:

Microbial exposures have been suggested to confer protection from allergic disorders and reduced exposures to gastrointestinal microbiota have been proposed as an explanation for the increase in asthma prevalence. Since the general prevalence of Helicobacter pylori has been decreasing, we hypothesized that H. pylori serostatus would be inversely related to the presence of asthma.

METHODS:

Adults were recruited to participate in the New York University (NYU)/Bellevue Asthma Registry in New York City. Adult asthma cases (N = 318) and controls (N = 208) were identified and serum IgG antibodies to H. pylori whole cell antigens or the immunodominant CagA antigen were measured.

RESULTS:

As expected, the asthma cases and controls differed with respect to atopy and lung function. Seropositivity to H. pylori or CagA antigen was present in 47.1% of the total case and control study population. Asthma was inversely associated with CagA seropositivity (OR = 0.57, 95% CI = 0.36-0.89). Median age of onset of asthma (doctor's diagnosis) was older (21 years) among individuals with CagA+ strains than among H. pylori- individuals (11 years) (p = 0.006).

CONCLUSION:

These data are consistent with the hypothesis that colonization with CagA+ H. pylori strains is inversely associated with asthma and is associated with an older age of asthma onset in an urban population. The data suggest H. pylori as a marker for protection.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT00212537.

PMID:
19112508
PMCID:
PMC2603593
DOI:
10.1371/journal.pone.0004060
[Indexed for MEDLINE]
Free PMC Article
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