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Cancer Cell. 2009 Jan 6;15(1):7-8. doi: 10.1016/j.ccr.2008.12.012.

Curing APL: differentiation or destruction?

Author information

  • 1Department of Laboratory Medicine and Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94143, USA. scott.kogan@ucsf.edu

Abstract

In a recent issue of Nature Medicine, Nasr et al. show that the effectiveness of all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia is independent of their ability to cause differentiation. Targeted destruction of the PML-RARalpha oncoprotein appears key to eliminating the cells from which relapse can arise.

PMID:
19111876
DOI:
10.1016/j.ccr.2008.12.012
[PubMed - indexed for MEDLINE]
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