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Cancer Cell. 2009 Jan 6;15(1):1-2. doi: 10.1016/j.ccr.2008.12.007.

The metastasis problem gets stickier.

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1
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

Abstract

The enormity and complexity of cancer genome data present significant challenges in downstream validation of novel oncogenes and tumor suppressors. In this issue of Cancer Cell, Hu et al. evaluate candidate oncogenes in a recurrent amplification in poor-prognosis breast cancers. They identify and validate the prometastatic gene metadherin (MTDH) as a key modulator of endothelial adhesion and chemoresistance.

PMID:
19111873
DOI:
10.1016/j.ccr.2008.12.007
[Indexed for MEDLINE]
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