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Cancer Lett. 2009 Apr 18;276(2):196-203. doi: 10.1016/j.canlet.2008.11.024. Epub 2008 Dec 25.

Breast cancer metastasis suppressor 1 (BRMS1) suppresses metastasis and correlates with improved patient survival in non-small cell lung cancer.

Author information

1
Department of Surgery, University of Virginia, Charlottesville Virginia, P.O. Box 800679, Charlottesville, VA 22908-0679, United States.
2
Department of Pathology, University of Virginia, Charlottesville Virginia, P.O. Box 800679, Charlottesville, VA 22908-0679, United States.
3
Department of Public Health Sciences, University of Virginia, Charlottesville Virginia, P.O. Box 800679, Charlottesville, VA 22908-0679, United States.
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Contributed equally

Abstract

Breast cancer metastasis suppressor 1 (BRMS1) is a metastasis suppressor gene in several solid tumors. The role of BRMS1 in non-small cell lung cancer (NSCLC) is not well established. To assess in vitro and in vivo metastatic behavior H1299 NSCLC cells stably expressing BRMS1 or a vector control were created. BRMS1 expression significantly decreases both migration and invasion of NSCLC cells in vitro. Importantly, in flank xenografts, BRMS1 suppresses the formation of pulmonary and hepatic metastases but does not significantly affect primary tumor growth. To evaluate whether BRMS1 is related to the progression of NSCLC, we examined BRMS1 expression in human NSCLC. Both BRMS1 mRNA and protein levels are diminished in NSCLC compared to adjacent non-cancerous lung. BRMS1 expression is also lower in squamous cell carcinoma compared to adenocarcinoma. Moreover, preservation of tumor BRMS1 expression is associated with improved patient survival. Thus, BRMS1 functions as a metastasis suppressor and may be a prognostic indicator for human NSCLC.

PMID:
19111386
PMCID:
PMC4793277
DOI:
10.1016/j.canlet.2008.11.024
[Indexed for MEDLINE]
Free PMC Article
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