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J Pediatr. 2009 Apr;154(4):498-503.e2. doi: 10.1016/j.jpeds.2008.10.044. Epub 2008 Dec 25.

Maternal age, multiple birth, and extremely low birth weight infants.

Collaborators (239)

Jobe A, Oh W, Laptook AR, Vogt RA, Hensman A, Noel L, Alksninis B, Lainwala S, Leach TM, Leonard MR, Mehta K, Moore J, Stephens B, Watson VE, Fanaroff AA, Walsh MC, Wilson-Costello D, Newman NS, Siner BS, Friedman HG, Stork E, Goldberg RN, Cotton CM, Goldstein RF, Auten KJ, Lohmeyer MB, Gustafson K, Stoll BJ, Jain L, Adams-Chapman I, Simon NP, Hale EC, LaRossa MM, Black L, Carter S, Dinkins E, Miller J, Seabrook I, Smikle G, Tidwell M, Higgins RD, McClure EM, Verter J, Powers T, Stark AR, Lee KG, Fournier K, Dow S, Driscoll C, Lemons JA, Poindexter BB, Dusick AM, Sokol G, Bull M, Kardatzke D, Lytle C, Appel DD, Herron D, Miller L, Richard L, Wilson LD, Bohnke LG, Eaken G, Cook A, Minnich H, Das A, Hastings B, Huitema CP, Mc-Clure E, Zaterka-Baxter K, Schaefer SE, Auman JO, Stevenson DK, Van Meurs KP, Hintz SR, Ball MB, Adams MM, Baran JM, Bond LE, Brudos G, DeAnda ME, DeBattista AM, Fleisher BE, Hajdena-Dawson M, Kohn J, Kuelper CG, Lee JC, Proud MS, Pyle RP, Sivakumar D, St John N, Carlo WA, Ambalavanan N, Peralta-Carcelen M, Collins MV, Cosby SS, Phillips V, Bailey KJ, Biasini FJ, Chopko SA, Preskitt J, Moses M, Nelson K, Rector RV, Whitley S, Finer NN, Rasmussen MR, Vaucher YE, Arnell K, Demetrio C, Fuller MG, Henderson C, Rich W, Barbieri-Welge R, Ben-Tall A, Ito E, Lukasik M, Pontillo D, Posin D, Runyan C, Wilkes J, Donovan EF, Steichen J, Schibler K, Bridges K, Fridriksson J, Alexander B, Grisby C, Gratton TL, Mersmann M, Mincey H, Shively J, Duara S, Bauer CR, Hiriart-Fajardo S, Everett-Thomas R, Allison M, Azemar C, Calejo M, Diaz AN, Eguaras SM, Gideon YC, Griffin W, Guzman R, Hamlin-Smith K, Jacque E, Jean-Gilles L, Londono A, Mathews EO, Stroerger A, Papile LA, Lacy CB, Lowe J, Laadt G, Long DV, Phelps DL, Guillet R, Myers GJ, D'Angio CT, Reubens LJ, Hust D, Jensen RL, Burnell E, Johnson JB, Horihan CA, Kushner E, Merzbach J, Rowan G, Yost K, Zwetsch L, Mossgraber K, Korones SB, Bada HS, Yolton K, Hudson T, Laptook AR, Rosenfeld CR, Salhab WA, Broyles RS, Heyne RJ, Uauy RD, Madison S, Hickman JF, Hensley G, Miller NA, Morgan JS, Adams S, Boatman C, Dooley C, Guzman A, Heyne E, Lupino C, Madden L, Kennedy KA, Morris BH, Bradt PJ, Evans PW, Major-Kincade T, Whitely LL, Akpa EG, Cedillo M, Cluff PA, Lis AE, McDavid GE, Franco CY, Alaniz NI, Dieterich S, Reddoch S, Tate PL, O'Shea TM, Dillard RG, Washburn LK, Peters NJ, Jackson BG, Allred D, Chiu K, Goldstein D, Halfond R, Heller C, Hounshell G, Morris M, Peterson C, Waldrep E, Shankaran S, Johnson Y, Pappas A, Bara R, Muran G, Kennedy D, Goldston L, Ehrenkranz RA, Gross I, Kaplan MD, Mayes L, Gettner P, Konstantino M, Romano E, Cervone P, Close N.

Author information

1
Department of Pediatrics, The Warren Alpert Medical School of Brown University, Providence, RI, USA.

Abstract

OBJECTIVES:

To compare the rates of adverse neurodevelopmental outcome or death at 18 to 22 months among extremely low birth weight (ELBW) infants born to mothers >or=4 0 years to the corresponding rates among infants of younger mothers.

STUDY DESIGN:

Prospective evaluation of ELBW infants to quantify the relative risks of maternal age and multiple birth for death or adverse neurodevelopmental outcome.

RESULTS:

The sample consisted of 14 671 live ELBW births divided into maternal age groups: <20, 20 to 29, 30 to 39, and >or= 40 years. Of infants born to mothers >or= 40 years, 20% were multiples. Mothers >or= 40 years had high rates of obstetric interventions and medical morbidities compared with mothers <40 years. ELBW live births of mothers >or= 40 years were 22% more likely to survive and had a 13% decreased risk of neurodevelopmental impairment or death compared with mothers <20. Multiple birth, however, was associated with a 10% greater risk of neurodevelopmental impairment or death.

CONCLUSION:

Although mothers >or= 40 years had high pregnancy-related morbidities, we found no overall increased risk of the composite outcome of death or NDI. Multiple birth, however, was a predictor of all adverse outcomes examined, regardless of maternal age.

PMID:
19111322
PMCID:
PMC2834530
DOI:
10.1016/j.jpeds.2008.10.044
[Indexed for MEDLINE]
Free PMC Article

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