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J Pediatr. 2009 May;154(5):715-20. doi: 10.1016/j.jpeds.2008.10.046. Epub 2008 Dec 25.

Adipose tissue infiltration of skeletal muscle in children with cerebral palsy.

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  • 1Department of Health, Nutrition and Exercise Sciences, University of Delaware, Newark, DE 19716, USA.

Abstract

OBJECTIVE:

To determine whether children with quadriplegic cerebral palsy (QCP) have a greater adipose tissue (AT) infiltration of skeletal muscle than typically developing children (12/group and 5-14 years).

STUDY DESIGN:

Cross-sectional area (CSA) of AT and muscle in the midthigh were assessed with magnetic resonance imaging. Physical activity was assessed with an activity monitor.

RESULTS:

Children with QCP had 2.3-fold higher intermuscular AT CSA and 51% lower muscle CSA in the midthigh than control subjects. Midthigh intermuscular, subfascial, and subcutaneous AT CSA adjusted for midthigh muscle CSA were higher in children with QCP (all P < .05). Moreover, the proportion of intermuscular AT CSA and subfascial AT CSA relative to subcutaneous AT CSA in the midthigh were 2.5-fold and 1.8-fold higher in children with QCP than control subjects (all P < .05). Children with QCP also had 70% fewer physical activity counts, which was inversely related to intermuscular AT CSA (r = -0.76) and subfascial AT CSA (r = -0.63) adjusted for muscle CSA in the midthigh of children with QCP (both P < 0.05), but not in control subjects.

CONCLUSION:

Children with QCP have a greater AT infiltration of skeletal muscle than typically developing children, which is related to their low level of physical activity.

PMID:
19111321
PMCID:
PMC2963648
DOI:
10.1016/j.jpeds.2008.10.046
[PubMed - indexed for MEDLINE]
Free PMC Article
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