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J Hepatobiliary Pancreat Surg. 2009;16(2):101-12. doi: 10.1007/s00534-008-0021-2. Epub 2008 Dec 26.

Current status of islet cell transplantation.

Author information

1
Cell Transplant Center, Diabetes Research Institute, University of Miami Leonard M Miller School of Medicine, Miami, FL 33136, USA. hichii@med.miami.edu

Abstract

Despite substantial advances in islet isolation methods and immunosuppressive protocol, pancreatic islet cell transplantation remains an experimental procedure currently limited to the most severe cases of type 1 diabetes mellitus. The objectives of this treatment are to prevent severe hypoglycemic episodes in patients with hypoglycemia unawareness and to achieve a more physiological metabolic control. Insulin independence and long term-graft function with improvement of quality of life have been obtained in several international islet transplant centers. However, experimental trials of islet transplantation clearly highlighted several obstacles that remain to be overcome before the procedure could be proposed to a much larger patient population. This review provides a brief historical perspective of islet transplantation, islet isolation techniques, the transplant procedure, immunosuppressive therapy, and outlines current challenges and future directions in clinical islet transplantation.

PMID:
19110649
PMCID:
PMC3777531
DOI:
10.1007/s00534-008-0021-2
[Indexed for MEDLINE]
Free PMC Article
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