Format

Send to

Choose Destination
Cell Signal. 2009 Apr;21(4):470-6. doi: 10.1016/j.cellsig.2008.11.015. Epub 2008 Dec 7.

Function of Akt/PKB signaling to cell motility, invasion and the tumor stroma in cancer.

Author information

1
Department of Pathology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, EC/CLS-528, Boston, MA 02215, USA. rchin1@bidmc.harvard.edu

Abstract

The serine/threonine protein kinase Akt is a major signal transducer of the phosphoinositide 3-kinase (PI 3-K) pathway in all cells and tissues and plays a pivotal role in the maintenance of cellular processes including cell growth, proliferation, survival and metabolism. The frequent aberrant activation of the PI 3-K/Akt pathway in human cancer has made it an attractive therapeutic target. Numerous studies have provided a comprehensive understanding of the specific functions of Akt signaling in cancer cells as well as the surrounding tumor microenvironment and this has informed and enabled the development of therapeutic drugs to target both PI 3-K and Akt. However, recent studies have provided evidence for distinct functions of the three mammalian Akt isoforms, particularly with respect to the regulation of cell motility and metastasis of breast cancer. Here we discuss the mechanisms by which Akt signaling contributes to invasive migration and tumor metastasis, and highlight recent advances in our understanding of the contribution of the Akt pathway in the tumor-associated stroma.

PMID:
19110052
PMCID:
PMC2719559
DOI:
10.1016/j.cellsig.2008.11.015
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center