Format

Send to

Choose Destination
See comment in PubMed Commons below
Neuron. 2008 Dec 26;60(6):961-74. doi: 10.1016/j.neuron.2008.10.012.

Decoding the epigenetic language of neuronal plasticity.

Author information

1
Department of Microbiology and Molecular Genetics, University of California, Irvine, CA 92697, USA.

Abstract

Neurons are submitted to an exceptional variety of stimuli and are able to convert these into high-order functions, such as storing memories, controlling behavior, and governing consciousness. These unique properties are based on the highly flexible nature of neurons, a characteristic that can be regulated by the complex molecular machinery that controls gene expression. Epigenetic control, which largely involves events of chromatin remodeling, appears to be one way in which transcriptional regulation of gene expression can be modified in neurons. This review will focus on how epigenetic control in the mature nervous system may guide dynamic plasticity processes and long-lasting cellular neuronal responses. We outline the molecular pathways underlying chromatin transitions, propose the presence of an "epigenetic indexing code," and discuss how central findings accumulating at an exponential pace in the field of epigenetics are conceptually changing our perspective of adult brain function.

PMID:
19109904
PMCID:
PMC2737473
DOI:
10.1016/j.neuron.2008.10.012
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center