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Neuron. 2008 Dec 26;60(6):950-60. doi: 10.1016/j.neuron.2008.12.007.

Reversing neurodevelopmental disorders in adults.

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1
Department of Neurobiology, Psychiatry and Biobehavioral Sciences, Psychology and the Brain Research Institute, University of California Los Angeles, Los Angeles, CA 90095-1761, USA.

Abstract

Abnormalities in brain development, thought to be irreversible in adults, have long been assumed to underlie the neurological and psychiatric symptoms associated with neurodevelopmental disorders. Surprisingly, a number of recent animal model studies of neurodevelopmental disorders demonstrate that reversing the underlying molecular deficits can result in substantial improvements in function even if treatments are started in adulthood. These findings mark a paradigmatic change in the way we understand and envision treating neurodevelopmental disorders.

PMID:
19109903
PMCID:
PMC2710296
DOI:
10.1016/j.neuron.2008.12.007
[Indexed for MEDLINE]
Free PMC Article
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