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Cell. 2008 Dec 26;135(7):1165-7. doi: 10.1016/j.cell.2008.12.005.

Mitofusin 2 builds a bridge between ER and mitochondria.

Author information

1
Institute for Genetics, Centre for Molecular Medicine (CMMC), University of Cologne, 50674 Cologne, Germany.

Abstract

Mutations in mitofusin 2 (MFN2), a dynamin-like GTPase required for mitochondrial fusion, cause the peripheral neuropathy Charcot-Marie-Tooth type 2A. In a recent report in Nature, de Brito and Scorrano (2008) demonstrate a new function of MFN2-tethering the endoplasmic reticulum and mitochondria to control the efficiency of mitochondrial uptake of Ca2+ ions.

PMID:
19109886
DOI:
10.1016/j.cell.2008.12.005
[Indexed for MEDLINE]
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