Format

Send to

Choose Destination
See comment in PubMed Commons below
BMC Bioinformatics. 2008 Dec 25;9:557. doi: 10.1186/1471-2105-9-557.

SimHap GUI: an intuitive graphical user interface for genetic association analysis.

Author information

1
Western Australian Institute for Medical Research and UWA Centre for Medical Research, University of Western Australia, Perth, Australia. kcarter@ichr.uwa.edu.au

Abstract

BACKGROUND:

Researchers wishing to conduct genetic association analysis involving single nucleotide polymorphisms (SNPs) or haplotypes are often confronted with the lack of user-friendly graphical analysis tools, requiring sophisticated statistical and informatics expertise to perform relatively straightforward tasks. Tools, such as the SimHap package for the R statistics language, provide the necessary statistical operations to conduct sophisticated genetic analysis, but lacks a graphical user interface that allows anyone but a professional statistician to effectively utilise the tool.

RESULTS:

We have developed SimHap GUI, a cross-platform integrated graphical analysis tool for conducting epidemiological, single SNP and haplotype-based association analysis. SimHap GUI features a novel workflow interface that guides the user through each logical step of the analysis process, making it accessible to both novice and advanced users. This tool provides a seamless interface to the SimHap R package, while providing enhanced functionality such as sophisticated data checking, automated data conversion, and real-time estimations of haplotype simulation progress.

CONCLUSION:

SimHap GUI provides a novel, easy-to-use, cross-platform solution for conducting a range of genetic and non-genetic association analyses. This provides a free alternative to commercial statistics packages that is specifically designed for genetic association analysis.

PMID:
19109877
PMCID:
PMC2639440
DOI:
10.1186/1471-2105-9-557
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for BioMed Central Icon for PubMed Central
    Loading ...
    Support Center