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Nat Chem Biol. 2009 Feb;5(2):94-6. doi: 10.1038/nchembio.135. Epub 2008 Dec 21.

Cytochrome bd confers nitric oxide resistance to Escherichia coli.

Author information

1
Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, UK.

Abstract

The aerobic respiratory chain of Escherichia coli has two terminal quinol oxidases: cytochrome bo and cytochrome bd. Cytochrome bd was thought to function solely to facilitate micro-aerobic respiration. However, it has recently been shown to be overexpressed under conditions of nitric oxide (NO) stress; we show here that cytochrome bd is crucial for protecting E. coli cells from NO-induced growth inhibition by virtue of its fast NO dissociation rate.

PMID:
19109594
DOI:
10.1038/nchembio.135
[Indexed for MEDLINE]

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