Cytochrome bd confers nitric oxide resistance to Escherichia coli

Nat Chem Biol. 2009 Feb;5(2):94-6. doi: 10.1038/nchembio.135. Epub 2008 Dec 21.

Abstract

The aerobic respiratory chain of Escherichia coli has two terminal quinol oxidases: cytochrome bo and cytochrome bd. Cytochrome bd was thought to function solely to facilitate micro-aerobic respiration. However, it has recently been shown to be overexpressed under conditions of nitric oxide (NO) stress; we show here that cytochrome bd is crucial for protecting E. coli cells from NO-induced growth inhibition by virtue of its fast NO dissociation rate.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cytochrome b Group
  • Cytochromes / metabolism*
  • Electron Transport Chain Complex Proteins / metabolism*
  • Escherichia coli / enzymology
  • Escherichia coli / growth & development
  • Escherichia coli / metabolism*
  • Escherichia coli Proteins / metabolism*
  • Nitric Oxide / metabolism*
  • Oxidoreductases / metabolism*

Substances

  • Cytochrome b Group
  • Cytochromes
  • Electron Transport Chain Complex Proteins
  • Escherichia coli Proteins
  • Nitric Oxide
  • Oxidoreductases
  • cytochrome bd terminal oxidase complex, E coli

Associated data

  • PubChem-Substance/56412693
  • PubChem-Substance/56412694
  • PubChem-Substance/56412695
  • PubChem-Substance/56412696
  • PubChem-Substance/56412697
  • PubChem-Substance/56412698