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J Virol. 2009 Mar;83(6):2770-7. doi: 10.1128/JVI.01841-08. Epub 2008 Dec 24.

Gag p27-specific B- and T-cell responses in Simian immunodeficiency virus SIVagm-infected African green monkeys.

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1
Institut Pasteur, Régulation des Infections Rétrovirales, Paris, France.

Abstract

Nonpathogenic simian immunodeficiency virus SIVagm infection of African green monkeys (AGMs) is characterized by the absence of a robust antibody response against Gag p27. To determine if this is accompanied by a selective loss of T-cell responses to Gag p27, we studied CD4(+) and CD8(+) T-cell responses against Gag p27 and other SIVagm antigens in the peripheral blood and lymph nodes of acutely and chronically infected AGMs. Our data show that AGMs can mount a T-cell response against Gag p27, indicating that the absence of anti-p27 antibodies is not due to the absence of Gag p27-specific T cells.

PMID:
19109377
PMCID:
PMC2648264
DOI:
10.1128/JVI.01841-08
[Indexed for MEDLINE]
Free PMC Article
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