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Eur J Nucl Med Mol Imaging. 2009 May;36(5):780-90. doi: 10.1007/s00259-008-1024-6. Epub 2008 Dec 24.

Induction of iodide uptake in transformed thyrocytes: a compound screening in cell lines.

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1
Department of Endocrinology, Metabolism, Nephrology and Clinical Chemistry, Internal Medicine, University of Tuebingen, Tuebingen, Germany.

Abstract

PURPOSE:

Retinoic acid presently is the most advanced agent able to improve the efficacy of radioiodine therapy in differentiated thyroid carcinoma. In order to identify compounds with higher efficacy a panel of pharmacologically well-characterized compounds with antitumour action in solid cancer cell lines was screened.

METHODS:

The effects of the compounds on iodide uptake, cell number, proliferation and apoptosis were evaluated.

RESULTS:

In general, compounds were more effective in cell lines derived from more aggressive tumours. The effectiveness in terms of number of responsive cell lines and maximal increase in iodide uptake achieved decreased in the order: APHA > valproic acid approximately sirolimus approximately arsenic trioxide > retinoic acid approximately lovastatin > apicidine approximately azacytidine approximately retinol approximately rosiglitazone approximately bortezomib.

CONCLUSION:

We hypothesize that testing of cells from primary tumours or metastases in patients may be a way to identify compounds with optimum therapeutic efficacy for individualized treatment.

PMID:
19107477
DOI:
10.1007/s00259-008-1024-6
[Indexed for MEDLINE]
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