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Lab Chip. 2009 Jan 21;9(2):193-5. doi: 10.1039/b813204f. Epub 2008 Nov 12.

Optical aggregation of metal nanoparticles in a microfluidic channel for surface-enhanced Raman scattering analysis.

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1
Department of Applied Physics, Chalmers University of Technology, 41296, Göteborg, Sweden.

Abstract

Aggregated metal nanoparticles exhibit enhanced localized electromagnetic fields that enable highly sensitive vibrational spectroscopy analysis based on surface-enhanced Raman scattering (SERS). We demonstrate SERS detection of organic analytes adsorbed to optically aggregated silver nanoparticles in a microfluidic device. The combination of optical tweezers and microfluidics technologies paves the way for novel lab-on-a-chip based plasmonic chemo/bio sensors and overcomes two important drawbacks of standard SERS sensing schemes; i.e. the renewal of nanofabricated metallic substrates and the difficulty of avoiding uncontrolled aggregation in metal colloids.

PMID:
19107272
DOI:
10.1039/b813204f
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