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Biol Direct. 2008 Dec 23;3:54. doi: 10.1186/1745-6150-3-54.

A DNA topoisomerase IB in Thaumarchaeota testifies for the presence of this enzyme in the last common ancestor of Archaea and Eucarya.

Author information

1
Laboratoire de Chimie Bactérienne, Université de Provence, Aix-Marseille I, CNRS UPR9043, IFR88, Marseille, France. celine.brochier@ibsm.cnrs-mrs.fr

Abstract

DNA topoisomerase IB (TopoIB) was thought for a long time to be a eukaryotic specific enzyme. A shorter version was then found in viruses and later on in several bacteria, but not in archaea. Here, we show that a eukaryotic-like TopoIB is present in the recently sequenced genomes of two archaea of the newly proposed phylum Thaumarchaeota. Phylogenetic analyses suggest that a TopoIB was present in the last common ancestor of Archaea and Eucarya. This finding indicates that the last common ancestor of Archaea and Eucarya may have harboured a DNA genome.

PMID:
19105819
PMCID:
PMC2621148
DOI:
10.1186/1745-6150-3-54
[Indexed for MEDLINE]
Free PMC Article
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