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Climacteric. 2009 Apr;12(2):146-52. doi: 10.1080/13697130802607719.

Factors contributing to increased serum urate in postmenopausal Japanese females.

Author information

1
Department of Internal Medicine, Kinki Central Hospital, Hyogo, Japan.

Abstract

OBJECTIVE:

The level of serum urate is generally elevated in postmenopausal individuals. In addition to estrogen, other menopause-related factors may also affect uric acid metabolism in postmenopausal females. Accordingly, we investigated factors related to increased serum urate levels in addition to lack of estrogen.

SUBJECTS AND METHODS:

We studied 448 females who participated in an annual health check-up. None were being treated for gout, hyperuricemia, or diabetes mellitus, and no subjects had a history of hysterectomy and had never used estrogens or progestins. Body mass index (BMI), homeostasis model of insulin resistance (HOMA-R), and ethanol ingestion were investigated in all subjects, while information regarding menopause status was also obtained.

RESULTS:

Serum urate levels rose from the age of 46 to 60 years in the subjects. Multivariate regression analysis showed that BMI, HOMA-R, ethanol ingestion and menopause were independently associated with serum urate level. In addition, BMI and HOMA-R were higher in postmenopausal, as compared to premenopausal, subjects.

CONCLUSION:

Our results suggest that menopause-related insulin resistance, obesity and ethanol ingestion as well as menopause may contribute to an increase in level of serum urate in postmenopausal Japanese women.

PMID:
19105055
DOI:
10.1080/13697130802607719
[Indexed for MEDLINE]

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